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Scientific Reference
5-Hydroxytryptophan
1. Shell W, Bullias D, Charuvastra E, May LA, Silver DS. A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep. Am J Ther. 2010 Mar-Apr;17(2):133-9. doi: 10.1097/MJT.0b013e31819e9eab.
2. Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol. 1986;25(5):327-9. doi: 10.1159/000116030.
3. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002;(1):CD003198. doi: 10.1002/14651858.CD003198.
4. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord. 1998 Jul;22(7):648-54. doi: 10.1038/sj.ijo.0800642.
Stinging Nettle Leaf Powder
1. Najafipour F, Rahimi AO, Mobaseri M, Agamohamadzadeh N, Nikoo A, Aliasgharzadeh A. Therapeutic effects of stinging nettle (Urtica dioica) in women with hyperandrogenism. Int J Curr Res Aca Rev. 2014;2(7):153-160.
2. More M, Gruenwald J, Pohl U, Uebelhack R. A Rosa canina - Urtica dioica - Harpagophytum procumbens/zeyheri combination significantly reduces gonarthritis symptoms in a randomized, placebo-controlled double-blind study. Planta Med. 2017 Dec;83(18):1384-91.
3. Men C, Wang M, Aiyireti M, Cui Y. The efficacy and safety of Urtica dioica in treating benign prostatic hyperplasia: a systematic review and meta-analysis. Afr J Tradit Complement Alt Med 2016;13(2):143-50.
4. Ziaei R, Foshati S, Hadi A, et al. The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Phytother Res 2020;34(2):282-94.


Saffron Extract
1. Abedimanesh N, Bathaie SZ, Abedimanesh S, Motlagh B, Separham A, Ostadrahimi A. Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease. J Cardiovasc Thorac Res. 2017;9(4):200-208. doi: 10.15171/jcvtr.2017.35. Epub 2017 Dec 30. PMID: 29391933; PMCID: PMC5787332.
2. Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine. 2006 Nov;13(9-10):607-11. doi: 10.1016/j.phymed.2006.08.006. Epub 2006 Sep 18. PMID: 16979327.
3. Dwyer AV, Whitten DL, Hawrelak JA. Herbal medicines, other than St. John's Wort, in the treatment of depression: a systematic review. Altern Med Rev. 2011 Mar;16(1):40-9. PMID: 21438645.
4. Rezaee R, Hosseinzadeh H. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci. 2013 Jan;16(1):12-26. PMID: 23638289; PMCID: PMC3637901.
L-Tryptophan
1. Comai S, Bertazzo A, Brughera M, Crotti S. Tryptophan in health and disease. Adv Clin Chem. 2020;95:165-218. doi: 10.1016/bs.acc.2019.08.005. Epub 2019 Oct 15.
2. Friedman M. Analysis, Nutrition, and Health Benefits of Tryptophan. Int J Tryptophan Res. 2018 Sep 26;11:1178646918802282. doi: 10.1177/1178646918802282.
3. Fernstrom JD. Effects and side effects associated with the non-nutritional use of tryptophan by humans. J Nutr. 2012 Dec;142(12):2236S-2244S. doi: 10.3945/jn.111.157065. Epub 2012 Oct 17.
4. Höglund E, Øverli Ø, Winberg S. Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review. Front Endocrinol (Lausanne). 2019 Apr 8;10:158. doi: 10.3389/fendo.2019.00158. PMID: 31024440; PMCID: PMC6463810.
Green Tea Extract
1. Jówko E, Długołęcka B, Makaruk B, Cieśliński I. The effect of green tea extract supplementation on exercise-induced oxidative stress parameters in male sprinters. Eur J Nutr. 2015 Aug;54(5):783-91. doi: 10.1007/s00394-014-0757-1. Epub 2014 Aug 14.
2. Filippini T, Malavolti M, Borrelli F, Izzo AA, Fairweather-Tait SJ, Horneber M, Vinceti M. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database Syst Rev. 2020 Mar 2;3(3):CD005004. doi: 10.1002/14651858.CD005004.pub3.
3. Rondanelli M, Riva A, Petrangolini G, Allegrini P, Perna S, Faliva MA, Peroni G, Naso M, Nichetti M, Perdoni F, Gasparri C. Effect of Acute and Chronic Dietary Supplementation with Green Tea Catechins on Resting Metabolic Rate, Energy Expenditure and Respiratory Quotient: A Systematic Review. Nutrients. 2021 Feb 17;13(2):644. doi: 10.3390/nu13020644.
4. Basu A, Betts NM, Mulugeta A, Tong C, Newman E, Lyons TJ. Green tea supplementation increases glutathione and plasma antioxidant capacity in adults with the metabolic syndrome. Nutr Res. 2013 Mar;33(3):180-7. doi: 10.1016/j.nutres.2012.12.010. Epub 2013 Jan 30.


Caffeine Anhydrous
1. Grgic J, Grgic I, Pickering C, et alWake up and smell the coffee: caffeine supplementation and exercise performance—an umbrella review of 21 published meta-analysesBritish Journal of Sports Medicine 2020;54:681-688.
2. Trexler ET, Smith-Ryan AE, Roelofs EJ, Hirsch KR, Mock MG. Effects of coffee and caffeine anhydrous on strength and sprint performance. Eur J Sport Sci. 2016 Sep;16(6):702-10. doi: 10.1080/17461391.2015.1085097. Epub 2015 Sep 22.
3. Hodgson AB, Randell RK, Jeukendrup AE. The metabolic and performance effects of caffeine compared to coffee during endurance exercise. PLoS One. 2013;8(4):e59561. doi: 10.1371/journal.pone.0059561. Epub 2013 Apr 3.

Ashwagandha Root
1. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186.
2. Pérez-Gómez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis. Nutrients. 2020 Apr 17;12(4):1119. doi: 10.3390/nu12041119.
3. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. J Clin Psychiatry. 2013 Nov;74(11):1076-83. doi: 10.4088/JCP.13m08413.
4. Lopresti AL, Drummond PD, Smith SJ. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males. Am J Mens Health. 2019 Mar-Apr;13(2):1557988319835985. doi: 10.1177/1557988319835985.


L-Theanine
1. Giesbrecht T, Rycroft JA, Rowson MJ, De Bruin EA. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010 Dec;13(6):283-90. doi: 10.1179/147683010X12611460764840.
2. Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362.
Valerian Root Extract
1. Tammadon MR, Nobahar M, Hydarinia-Naieni Z, Ebrahimian A, Ghorbani R, Vafaei AA. The Effects of Valerian on Sleep Quality, Depression, and State Anxiety in Hemodialysis Patients: A Randomized, Double-blind, Crossover Clinical Trial. Oman Med J. 2021 Mar 31;36(2):e255. doi: 10.5001/omj.2021.56.
2. Shinjyo N, Waddell G, Green J. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20967323. doi: 10.1177/2515690X20967323.

Passionflower Extract
1. Strasser M, Noriega P, Löbenberg R, Bou-Chacra N, Bacchi EM. Antiulcerogenic potential activity of free and nanoencapsulated Passiflora serratodigitata L. extracts. Biomed Res Int. 2014;2014:434067. doi: 10.1155/2014/434067. Epub 2014 Jul 13.
2. Sathish R, Sahu A, Natarajan K. Antiulcer and antioxidant activity of ethanolic extract of Passiflora foetida L. Indian J Pharmacol. 2011 May;43(3):336-9. doi: 10.4103/0253-7613.81501.
3. Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg. 2008 Jun;106(6):1728-32. doi: 10.1213/ane.0b013e318172c3f9.
4. Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res. 2011 Aug;25(8):1153-9. doi: 10.1002/ptr.3400. Epub 2011 Feb 3.

White Kidney Bean Extract Powder
1. Hutchins AM, Winham DM, Thompson SV. Phaseolus beans: impact on glycaemic response and chronic disease risk in human subjects. Br J Nutr. 2012 Aug;108 Suppl 1:S52-65. doi: 10.1017/S0007114512000761.
2. Obiro WC, Zhang T, Jiang B. The nutraceutical role of the Phaseolus vulgaris alpha-amylase inhibitor. Br J Nutr. 2008 Jul;100(1):1-12. doi: 10.1017/S0007114508879135. Epub 2008 Mar 11.
3. Geil PB, Anderson JW. Nutrition and health implications of dry beans: a review. J Am Coll Nutr. 1994 Dec;13(6):549-58. doi: 10.1080/07315724.1994.10718446.
L-Carnitine
1. Iliceto S, Scrutinio D, Bruzzi P, D'Ambrosio G, Boni L, Di Biase M, Biasco G, Hugenholtz PG, Rizzon P. Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. J Am Coll Cardiol. 1995 Aug;26(2):380-7. doi: 10.1016/0735-1097(95)80010-e.
2. Tempesta E, Troncon R, Janiri L, Colusso L, Riscica P, Saraceni G, Gesmundo E, Calvani M, Benedetti N, Pola P. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Int J Clin Pharmacol Res. 1990;10(1-2):101-7.
4. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016 Oct;17(10):970-6. doi: 10.1111/obr.12436. Epub 2016 Jun 22.

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